Antigen Recognition by Cd1a-Restricted T Cells in the Human Immune System

Grant number: 1122890 | Funding period: 2017 - 2018

Completed

Abstract

Human immunity requires protective T cells that target foreign molecules for removal. Even though substantial populations of T cells exist that recognise lipid molecules, little is known about their basic biology. We will identify and characterise lipid reactive human T cells and examine their response to foreign or self-lipids expressed by infectious organisms and host cells. This work will have important implications in understanding lipid reactive T cells in health and disease.

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University of Melbourne Researchers